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A tractor trailer and a CSX cargo train collided Tuesday afternoon, derailing about 15 train cars, rocking the Baltimore region with a huge explosion and sending a plume of smoke into the air that could be seen for miles, CBS News affiliate WJZ reports.

CSX spokesman Gary Sease said the train was en route from Silkirk, N.Y., to Waycross, Ga., when it collided just after 2 p.m. in Rosedale, just northeast of Baltimore City. Shocked residents said the ground shook and windows were blown, leading many to think and earthquake occurred or bomb had gone off.

WJZ’s Adam May reports the tractor trailer driver is in the hospital in serious but stable condition. No other injuries have been reported. Residents in the Pulaski/Moravia area are asked to stay indoors and police are telling people to evacuate from the 20 blocks around the incident.

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